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Studies & Research


Studies into medicinal benefits of cannabis creams and salves.

There has been substantial research into the medicinal benefits of cannabis extracts applied to the skin. Here is a selection of recent studies:


Article: Topical Uses for Cannabis Sativa
(East West School of Herbology, 2014) 

Broad overview of medicinal cannabinoids and the use of topical cannabis creams.


Article: Cannabinoid system in the skin - future therapies in dermatology
(Journal of Experimental Dermatology, July 2006)

Excellent overview. Summarizes current knowledge about the cannabinoid system in the skin. Concludes that "the therapeutic possibilities of cannabinoid usage in skin diseases seem to be unquestionable."


Study: Anti-inflammatory activity of topical THC in allergic contact dermatitis
(Journal Allergy, 2013)

"Topically applied THC can effectively attenuate contact allergic inflammation. This has important implications for cannabinoids for the treatment of inflammatory skin diseases."


Article: New frontier for medical cannabis -- topical pot
(SF Gate Chronicle, 2007)

"Mice healed faster from skin allergies with topical THC, the main psychoactive ingredient in marijuana."


Study: Constituents Of Hashish And Marijuana May Help To Fight Inflammation And Allergies
(University of Bonn, 2007)

"A solution with an important component made from cannabis reduced allergic reactions of the skin. The results open up new options for the treatment of skin allergies and inflammation."


Study: Cannabinoids have a potential therapeutic value in the treatment of psoriasis
(Journal of Dermatological Science, 2007)

"Our results support a potential role for cannabinoids in the treatment of psoriasis."


Study: Topical cannabinoid cream for postherpetic neuralgia
(Dutch Journal of Dermatology, 2007)

"Topical cannabinoids are an effective and well-tolerated adjuvant therapy option in postherpetic neuralgia."


Study: Topical cannabinoid cream for chronic, therapy-resistant pruritus
(Journal Hautarzt - Dermatology, 2006)

"In 14 of 22 patients a good antipruritic effect could be documented. Topical cannabinoid agonists represent a new effective and well-tolerated therapy for refractory itching of various origins."


Study: Cannabinoid agonists attenuate capsaicin-induced responses in human skin
(International Association for the Study of Pain, 2003)

"The present study provided evidence for analgesic and anti-hyperalgesic properties of a topically applied cannabinoid receptor ligand, which might have important therapeutic implications in humans."


Study: Topical cannabinoid antinociception: synergy with spinal sites
(International Association for the Study of Pain, 2003)

"Results indicate that topically administered cannabinoid agonists may reduce pain without dysphoric side effects and abuse potential."


Study: Topical cannabinoid enhances pain relief of topical morphine
(International Association for the Study of Pain, 2003)

"These results demonstrate an antinociceptive (pain-reducing) interaction between topical opioids with topical, and spinal cannabinoids."


Study: Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin
(Journal of Dermatological Science, 2005)

"The abundant distribution of cannabinoid receptors on skin nerve fibers and mast cells provides implications for an anti-inflammatory, anti-nociceptive action of cannabinoid receptor agonists and suggests their putatively broad therapeutic potential."


Study: Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin
(Journal Inflammation Research, 2003)

"Experimentally induced itch was significantly reduced. Additionally, skin blood flow and neurogenic mediated flare responses were attenuated."


Study: Cannabinoid agonists attenuate capsaicin-induced pain responses in human skin
(Journal Pain, 2002)

"We demonstrated that pre-treatment with a cannabinoid significantly reduced the perception of pain following the administration of capsaicin. The present study provided evidence for analgesic and anti-hyperalgesic properties of a topically applied cannabinoid receptor ligand, which might have important therapeutic implications in humans."


Study: Efficacy and tolerance of the cream containing endocannabinoids in the treatment of uremic pruritus: a preliminary study.
(Journal of the Croatian Dermatovenerological Society, 2005)

"After 3-week therapy pruritus was completely eliminated in 38% of patients, and complete reduction of xerosis in 81%. The test product appeared to be effective in reducing both pruritus and xerosis in hemodialysis patients."


Article: Cannabis Topicals May Aid In Alcoholism Treatment
(Medical Jane, 2013)

"The topical CBD treatment had better results in terms of protecting the brain from degradation. The study suggests that topical cannabis extracts may be an equally effective method of introducing cannabinoids to the bloodstream."


Study: Transdermal delivery of cannabidiol attenuates binge alcohol-induced neurodegeneration
(Journal of Pharmacology, Biochemistry and Behavior, 2013)

"The CBD gel resulted in a 48% reduction in neurodegeneration. These results demonstrate the feasibility of using CBD transdermal delivery systems for the treatment of alcohol-induced neurodegeneration."


Study: Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model.
(Journal of Controlled Release, 2003)

"Transdermal application of ethosomal CBD prevented the inflammation and edema induced in the animal model, demonstrating the potential of transdermal CBD to be used as an anti-inflammatory treatment."


Study: Topical cannabinoids reduce hyperalgesia and inflammation
(International Association for the Study of Pain, 1998)

"Our results indicate that cannabinoids produce antihyperalgesia... and that cannabinoids reduce inflammation."